The approved weight-management titration (Wegovy) begins at 0.25 mg once weekly and escalates every four weeks toward a 2.4 mg maintenance dose. The diabetes product (Ozempic) starts at the same 0.25 mg and steps up to a 0.5 mg, then 1 mg, and up to a 2 mg maintenance dose, so the schedule depends on which product a figure comes from.[1][2]
Reviewed for accuracy · Last reviewed July 7, 2026A typical weight-management titration steps up every four weeks:
At the example 2.5 mg/mL concentration. For any other mix, use the calculator.
Like tirzepatide, semaglutide is sold as a fixed-dose pen, so people sourcing it as a vial usually convert milligrams to insulin-syringe units themselves. The units chart below is worked at one example concentration; recalculate for your own vial with the calculator.
This page is an independent educational reference and is not medical advice. Talk to a doctor before starting or adjusting any compound.