Sleep is a thin category for peptides. The compound most associated with it, DSIP, was named for a delta-sleep effect that later research struggled to confirm, and the pineal peptides sometimes mentioned alongside it have only loose, preclinical links to circadian rhythm. Treat this whole area as preliminary rather than a set of proven sleep aids.
Reviewed for accuracy · Last reviewed July 8, 2026The compounds below are the ones most discussed for sleep. Each links to its full profile, where the dosing, side effects, and sources live. They are ordered roughly by how much human evidence sits behind them, not by a claim that any one works.
DSIP is the only entry here with a name that directly references sleep, and even for DSIP the sleep hypothesis is contested: the peptide has never been tied to an isolated receptor, and the human data is old and inconsistent. The pineal peptides are included because of a plausible circadian link, not because trials show they improve sleep.
None of these has a standardized, clinically validated sleep protocol, and all are research-only compounds. Any specific dosing figures circulating online are anecdotal and not traceable to a peer-reviewed clinical standard, and product quality is an added variable.
This page is an independent educational reference and is not medical advice, and does not indicate any approval status for any use. Talk to a doctor before starting any compound.