Dosage guide

Tesamorelin Dosage

GHRH analog

Tesamorelin is dosed once daily, and the exact number depends on the formulation. The pivotal HIV lipodystrophy trials and the original Egrifta used 2 mg subcutaneously daily, while the reformulated EGRIFTA SV label specifies 1.4 mg once daily. It is the same molecule at different reconstituted concentrations.[1][2][3]

Reviewed for accuracy · Last reviewed July 7, 2026

Dosing

Clinical (approved use)2 mg, once daily
Common research range1–2 mg, once daily
Typical cycle length3–6 months in studies
Ranges reflect the approved label and published study protocols, not a prescribing guideline.

It is dosed daily rather than weekly because GHRH analogs are cleared quickly, and a daily injection maintains the intended pattern of the body's own growth-hormone release. In the trials, cycles ran for months, and the effect on visceral fat generally reversed after the compound was stopped.

FAQ

Is tesamorelin dosed at 2 mg or 1.4 mg?Both, depending on formulation. The pivotal trials and original Egrifta used 2 mg daily; the reformulated EGRIFTA SV label specifies 1.4 mg daily. Match the dose to the product you have.
Why is tesamorelin injected every day?GHRH analogs are cleared quickly, so daily dosing is used to maintain the intended rhythm of growth-hormone release. This differs from the once-weekly GLP-1 peptides.

References

  1. EGRIFTA SV (tesamorelin) for injection: FDA Prescribing InformationDailyMed (U.S. National Library of Medicine) / FDA · 2010 · DailyMed setid 3d783378-b02d-4f19-99dd-0fc91a042224 · NDA 022505
  2. Metabolic effects of a growth hormone-releasing factor in patients with HIVNew England Journal of Medicine · 2007 · PMID 18057338 · DOI 10.1056/NEJMoa072375
  3. Effect of Tesamorelin on Liver Fat and Visceral Fat in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Clinical TrialJAMA · 2014 · PMID 25038357 · DOI 10.1001/jama.2014.8334
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This page is an independent educational reference and is not medical advice. Talk to a doctor before starting any compound.