Dosage guide

Survodutide Dosage

GLP-1 / Glucagon

Survodutide has no approved label, so every dose figure here traces back to its published Phase 2 trials rather than a prescribing guideline. The obesity trial tested once-weekly subcutaneous doses of 0.6, 2.4, 3.6, and 4.8 mg, reached through a 20-week escalation followed by maintenance over 46 weeks total.[1][2]

Reviewed for accuracy · Last reviewed July 8, 2026

Dosing

Survodutide has no approved label, so these figures trace to its Phase 2 obesity trial, which escalated a once-weekly subcutaneous dose over 20 weeks before maintenance:

Escalation start0.6 mg weekly
Step up2.4 mg weekly
Step up3.6 mg weekly
Maintenance (max studied)4.8 mg weekly
Illustrative of the Phase 2 obesity trial protocol (0.6 – 4.8 mg weekly). The separate MASH trial escalated to as much as 6.0 mg weekly. Investigational; not a recommendation.

A separate Phase 2 MASH trial escalated further, testing 2.4, 4.8, and 6.0 mg weekly over 48 weeks. Because survodutide is still investigational, treat every number here as a description of what was studied, not a recommendation. Doses were stepped up gradually specifically to limit gastrointestinal side effects.

FAQ

What survodutide doses were used in trials?The Phase 2 obesity trial used once-weekly subcutaneous doses of 0.6, 2.4, 3.6, and 4.8 mg. The Phase 2 MASH trial tested 2.4, 4.8, and 6.0 mg weekly. There is no approved dose because survodutide remains investigational.
Why escalate the dose slowly?Gastrointestinal side effects were dose-related in both trials, so both protocols escalated the weekly dose gradually to keep nausea and related effects tolerable.

References

  1. Glucagon and GLP-1 Receptor Dual Agonist Survodutide for Obesity: A Randomised, Double-Blind, Placebo-Controlled, Dose-Finding Phase 2 TrialThe Lancet Diabetes & Endocrinology · 2024 · PMID 38330987 · DOI 10.1016/S2213-8587(23)00356-X · NCT04667377
  2. A Phase 2 Randomized Trial of Survodutide in MASH and FibrosisNew England Journal of Medicine · 2024 · PMID 38847460 · DOI 10.1056/NEJMoa2401755 · NCT04771273
Researching this protocol? PepHub can log weekly doses and track your titration.Download on the App Store

This page is an independent educational reference and is not medical advice, and does not indicate any approval status for any use. Survodutide is investigational. Talk to a doctor before starting any compound.