Dosage guide

Survodutide Dosage

GLP-1 / Glucagon

Survodutide has no approved label, so every dose figure here traces back to its published Phase 2 trials rather than a prescribing guideline. The obesity trial tested once-weekly subcutaneous doses of 0.6, 2.4, 3.6, and 4.8 mg, reached through a 20-week escalation followed by maintenance over 46 weeks total.[1][2]

Reviewed for accuracy · Last reviewed July 8, 2026

Dosing

Survodutide has no approved label, so these figures trace to its Phase 2 obesity trial, which escalated a once-weekly subcutaneous dose over 20 weeks before maintenance:

Escalation start0.6 mg weekly
Step up2.4 mg weekly
Step up3.6 mg weekly
Maintenance (max studied)4.8 mg weekly
Illustrative of the Phase 2 obesity trial protocol (0.6 – 4.8 mg weekly). The separate MASH trial escalated to as much as 6.0 mg weekly. Investigational; not a recommendation.

A separate Phase 2 MASH trial escalated further, testing 2.4, 4.8, and 6.0 mg weekly over 48 weeks. Because survodutide is still investigational, treat every number here as a description of what was studied, not a recommendation. Doses were stepped up gradually specifically to limit gastrointestinal side effects.

FAQ

What survodutide doses were used in trials?The Phase 2 obesity trial used once-weekly subcutaneous doses of 0.6, 2.4, 3.6, and 4.8 mg. The Phase 2 MASH trial tested 2.4, 4.8, and 6.0 mg weekly. There is no approved dose because survodutide remains investigational.
Why escalate the dose slowly?Gastrointestinal side effects were dose-related in both trials, so both protocols escalated the weekly dose gradually to keep nausea and related effects tolerable.

References

  1. Glucagon and GLP-1 Receptor Dual Agonist Survodutide for Obesity: A Randomised, Double-Blind, Placebo-Controlled, Dose-Finding Phase 2 TrialThe Lancet Diabetes & Endocrinology · 2024 · PMID 38330987 · DOI 10.1016/S2213-8587(23)00356-X · NCT04667377
  2. A Phase 2 Randomized Trial of Survodutide in MASH and FibrosisNew England Journal of Medicine · 2024 · PMID 38847460 · DOI 10.1056/NEJMoa2401755 · NCT04771273
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This page is an independent educational reference and is not medical advice, and does not indicate any approval status for any use. Survodutide is investigational. Talk to a doctor before starting any compound.