Dosage guide

Cagrilintide Dosage

Amylin analog

Cagrilintide has no approved label, so every dose figure here traces back to published trials rather than a prescribing guideline. The Phase 2 obesity monotherapy trial tested once-weekly subcutaneous doses of 0.3, 0.6, 1.2, 2.4, and 4.5 mg, reached through a dose-escalation period of up to six weeks before a 26-week treatment phase.[1][2][3]

Reviewed for accuracy · Last reviewed July 8, 2026

Dosing

The Phase 2 obesity trial escalated the once-weekly dose over about six weeks before a maintenance period:

Weeks 1–20.3 mg
Weeks 3–40.6 mg
Weeks 5–61.2 mg
Then maintenance2.4 mg or 4.5 mg
Illustrative escalation toward the higher study arms; the trial tested fixed doses of 0.3, 0.6, 1.2, 2.4, and 4.5 mg. Investigational, not a prescribing schedule.

In the semaglutide combination (CagriSema), the Phase 3 REDEFINE trials used a 2.4 mg cagrilintide maintenance dose paired with 2.4 mg semaglutide in a single once-weekly injection. The escalation table below mirrors the stepwise trial approach, but because cagrilintide is still investigational, treat these numbers as a description of what was studied, not a recommendation.

FAQ

What cagrilintide doses were used in trials?The Phase 2 obesity trial used once-weekly subcutaneous doses of 0.3, 0.6, 1.2, 2.4, and 4.5 mg, reached through an escalation of up to six weeks. The CagriSema combination used 2.4 mg cagrilintide. There is no approved dose because cagrilintide remains investigational.
Why escalate the dose gradually?Gastrointestinal side effects in the trials were dose-related, so stepping the dose up over several weeks is how studies aimed to keep nausea and related effects tolerable.

References

  1. Once-Weekly Cagrilintide for Weight Management in People With Overweight and Obesity: A Dose-Finding Phase 2 TrialThe Lancet · 2021 · PMID 34798060 · DOI 10.1016/S0140-6736(21)01751-7 · NCT03856047
  2. Cagrilintide-Semaglutide in Adults With Overweight or Obesity and Type 2 Diabetes (REDEFINE 2)New England Journal of Medicine · 2025 · PMID 40544432 · DOI 10.1056/NEJMoa2502082 · NCT05394519
  3. Investigation of Safety and Efficacy of NNC0174-0833 for Weight Management: A Dose-Finding TrialClinicalTrials.gov (sponsor: Novo Nordisk A/S) · 2019 · NCT03856047
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This page is an independent educational reference and is not medical advice, and does not indicate any approval status for any use. Talk to a doctor before starting any compound.