Dosage guide

VIP (Vasoactive Intestinal Peptide) Dosage

Endogenous neuropeptide / vasodilator

VIP has no approved dose for the uses discussed in the peptide community, so every figure here describes what a specific source reported rather than a prescribing guideline. The most commonly cited community regimen is intranasal, drawn from the CIRS literature; clinical aviptadil trials used their own separate protocols.[1][2]

Reviewed for accuracy · Last reviewed July 8, 2026

Dosing

There is no approved or validated dose for the community uses discussed here. The figures below simply describe what published sources reported, not a recommendation.

ContextReported regimen
Intranasal CIRS protocol (community)Commonly cited as 50 mcg per spray, four times daily
Inhaled aviptadil (phase 2 COVID-19 trial)100 mcg/mL solution, 2 mL once daily
The 50 mcg intranasal figure traces to a single small open-label CIRS study and is not a validated regimen. The inhaled aviptadil figure is from a clinical trial protocol, not a general dosing guideline.

The intranasal figure most often repeated is 50 mcg per spray, up to four times daily, taken from a single small open-label CIRS study in which patients later self-titrated downward. Because that study had no control group, this should be read as a description of what was done, not evidence that it is safe or effective.

Clinical aviptadil dosing is different again: the inhaled phase 2 COVID-19 trial used a 100 mcg/mL solution given once daily, while the intravenous program used continuous infusion protocols. None of these translate into a validated dose for personal research use.

FAQ

What intranasal VIP dose does the CIRS protocol use?It is commonly cited as 50 mcg per spray, four times daily, with self-titration downward. This traces to one small open-label study and is not a validated or approved regimen.
Is there an approved VIP dose?No. Neither the intranasal community use nor inhaled/IV aviptadil is FDA-approved, so there is no established prescribing dose. All figures here are descriptive only.

References

  1. Vasoactive intestinal polypeptide (VIP) corrects chronic inflammatory response syndrome (CIRS) acquired following exposure to water-damaged buildingsHealth (Scientific Research Publishing) · 2013 · DOI 10.4236/health.2013.53053
  2. Inhaled Aviptadil Is a New Hope for Recovery of Lung Damage due to COVID-19Medical Principles and Practice · 2025 · PMID 39870064 · DOI 10.1159/000543773
Tracking an intranasal protocol? PepHub can log doses, though remember this use is not validated.Coming soon

This page is an independent educational reference and is not medical advice, and does not indicate any approval status for any use. Talk to a doctor before starting any compound.